年級身份：
Postdoc
所屬的學校或研究單位：
Postdoc
所屬的學校或研究單位：
Biology and Biological Engineering, Caltech
研究興趣：
Neuroscience
研究興趣：
Neuroscience
簡述研究興趣：
I'm working on developing a synthetic and genetically-encoded system, TRanscellular ACtivation of Transcription (TRACT) to monitor cell-cell contact. Upon ligand-receptor interaction at sites of cell-cell contact, the transmembrane domain of an engineered Notch receptor is cleaved by intramembrane proteolysis and releases a fragment that regulates transcription in the receptor-expressing cell. We have previously demonstrated that TRACT is useful for monitoring cell-cell interactions in Drosophila and could also be used to genetically manipulate cells based on contact. Currently we are testing TRACT for tracing synaptic connections between neurons. Hopefully, in the future TRACT could be used to dissect neural circuits.
17' Talks
I'm working on developing a synthetic and genetically-encoded system, TRanscellular ACtivation of Transcription (TRACT) to monitor cell-cell contact. Upon ligand-receptor interaction at sites of cell-cell contact, the transmembrane domain of an engineered Notch receptor is cleaved by intramembrane proteolysis and releases a fragment that regulates transcription in the receptor-expressing cell. We have previously demonstrated that TRACT is useful for monitoring cell-cell interactions in Drosophila and could also be used to genetically manipulate cells based on contact. Currently we are testing TRACT for tracing synaptic connections between neurons. Hopefully, in the future TRACT could be used to dissect neural circuits.
17' Talks
- 1104 Monitoring cell-cell contacts in vivo in Drosophila [Link]
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