Title:
Identifying Potential Therapeutics for Modulating Neutrophil Inflammation
Identifying Potential Therapeutics for Modulating Neutrophil Inflammation
Speaker:
許翊輝 (Alan Y. Hsu), PhD student, Purdue University
許翊輝 (Alan Y. Hsu), PhD student, Purdue University
Time:
03/28 (Sat.) 3 pm PDT, 4 pm MDT, 5 pm CDT, 6 pm EDT
03/29 (Sun.) 6 am Taiwan
03/28 (Sat.) 3 pm PDT, 4 pm MDT, 5 pm CDT, 6 pm EDT
03/29 (Sun.) 6 am Taiwan
Keywords:
Biological sciences, Cell biology/immunology, Neutrophil, Cell migration, Inflammation, MicroRNA, Zebrafish
Biological sciences, Cell biology/immunology, Neutrophil, Cell migration, Inflammation, MicroRNA, Zebrafish
Abstract:
Neutrophils are the first cells recruited to an immune stimulus stemming from infection or sterile injuries via a mixture of chemoattractant cues. In addition to eliminating pathogens, neutrophils coordinate the overall inflammation by activating and producing inflammatory signals in the tissue while modulating the activation of other immune cells which in some cases leads to adverse tissue damage. Over amplified or chronic neutrophil recruitment directly leads to autoimmune diseases including rheumatic arthritis, diabetes, neurodegenerative diseases, and cancer. Dampening neutrophil recruitment is a strategy to intervene in neutrophil-orchestrated chronic inflammation. Despite intensive research, clinical studies targeting neutrophil migration have been largely unsuccessful, possibly due to the prominent redundancy of adhesion receptors and chemokines. Additional challenges lie in the balance of dampening detrimental inflammation while preserving immunity. We thus performed a neutrophil-specific microRNA (miRNA) overexpression screen in zebrafish and identified 9 miRNAs as potent suppressors of neutrophil migration.
Neutrophils are the first cells recruited to an immune stimulus stemming from infection or sterile injuries via a mixture of chemoattractant cues. In addition to eliminating pathogens, neutrophils coordinate the overall inflammation by activating and producing inflammatory signals in the tissue while modulating the activation of other immune cells which in some cases leads to adverse tissue damage. Over amplified or chronic neutrophil recruitment directly leads to autoimmune diseases including rheumatic arthritis, diabetes, neurodegenerative diseases, and cancer. Dampening neutrophil recruitment is a strategy to intervene in neutrophil-orchestrated chronic inflammation. Despite intensive research, clinical studies targeting neutrophil migration have been largely unsuccessful, possibly due to the prominent redundancy of adhesion receptors and chemokines. Additional challenges lie in the balance of dampening detrimental inflammation while preserving immunity. We thus performed a neutrophil-specific microRNA (miRNA) overexpression screen in zebrafish and identified 9 miRNAs as potent suppressors of neutrophil migration.
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