Title:
Understanding Biology by Replaying the Tape of Life: Experimental Evolution of Escherichia coli as an Example
Understanding Biology by Replaying the Tape of Life: Experimental Evolution of Escherichia coli as an Example
Time:
05/11 (Sat.) 8 pm PDT, 9 pm MDT, 10 pm CDT, 11 pm EDT
05/12 (Sun.) 11 am Taiwan
05/11 (Sat.) 8 pm PDT, 9 pm MDT, 10 pm CDT, 11 pm EDT
05/12 (Sun.) 11 am Taiwan
Keywords:
Biology, Evolutionary Biology, Microbiology
Biology, Evolutionary Biology, Microbiology
Abstract:
Where does the diversity of life come from? One way to study this question is to analyze natural data. However, the variables in natural system may be convoluted, which can hinder our ability to identify fundamental principles in evolution. To overcome it, evolutionary biologists started to perform experimental evolution in the lab, where the abiotic and biotic factors can be well controlled, and the evolutionary outcomes can be easily tracked. Particularly, we experimentally evolved bacteria Escherichia coli and used high-throughput sequencing to study how mutation rates affect evolutionary outcomes. Interestingly, the strains with high mutation rates accumulate mutations in higher rates (4-20 folds) and exhibit higher levels of mutational parallelism but do not show significant evidence for faster fitness improvement. These results suggest that clonal interference and evolvability of lower mutation rates are important in evolution. Moreover, the predictability of genomic evolution and fitness evolution are not necessarily coupled.
Where does the diversity of life come from? One way to study this question is to analyze natural data. However, the variables in natural system may be convoluted, which can hinder our ability to identify fundamental principles in evolution. To overcome it, evolutionary biologists started to perform experimental evolution in the lab, where the abiotic and biotic factors can be well controlled, and the evolutionary outcomes can be easily tracked. Particularly, we experimentally evolved bacteria Escherichia coli and used high-throughput sequencing to study how mutation rates affect evolutionary outcomes. Interestingly, the strains with high mutation rates accumulate mutations in higher rates (4-20 folds) and exhibit higher levels of mutational parallelism but do not show significant evidence for faster fitness improvement. These results suggest that clonal interference and evolvability of lower mutation rates are important in evolution. Moreover, the predictability of genomic evolution and fitness evolution are not necessarily coupled.
No comments:
Post a Comment